Similarly, the positive regulation of AXL, EGFR and PDGFRβ by RUNX2 could result in an activation of these receptors in the presence of their ligands (provided by melanoma cells or the melanoma cell microenvironment) thereby promoting stimulation of the PI3K and MAPK pathway and RUNX2 positive regulation (as shown in Figure 7). Here, EGFR is linked to melanoma.