Perrot et al. detected that in most non-small lung cancer cells, tumor-infiltrating DCs were immature and expressed none of the activation markers, CD80 or CD86 [17], which was consistent with our findings that TREM-2+DCs from CM and tumor-bearing mice presented CD80LowCD86LowMHCIILow phenotypes. This evidence concerns the gene TREM2 and neoplasm.