NOTCH3 and cancer: Although HeLa cells may not represent the best model to test cancer behaviors due to the dysfunctional LKB1/AMPK signaling, a recently demonstrated pathway modulating NADPH homeostasis and promoting tumor cell survival during energy stress [38], our rescue experiments indicate that NAC prevents malignant phenotypes through inhibition of Notch3 signaling also in the LKB1/AMPK-proficient HCC1937 cells.