However, we found interaction between CYP19A1/rs3751591 and PPARGC1A Gly482Ser (Pint = 0.02) in relation to BC risk (Additional file 7); and interaction between CYP19A1/rs4646 and PPARGC1A Thr612Met (Pint = 0.002) in relation to BC risk (Additional file 8). This evidence concerns the gene CYP19A1 and breast cancer.