Post hoc testing revealed that PSD-95 OD in the DG-IB and DG-OB was significantly decreased in PKU mice fed with diets without SNC compared to WT by 54% and 64%, respectively (Mann-Whitney U test DG-IB; p = 0.005, DG-OB; p = 0.005). The gene discussed is DLG4; the disease is phenylketonuria.