In a study comprising of 109 ICC, 40 ECC and 11 gallbladder cases, novel FGFR2 gene fusions (FGFR2-KCTD1 and FGFR2-TXLNA) and a new variation of FGFR2-BICC (Type 2) were reported [60]. This evidence concerns the gene BICC1 and intrahepatic cholangiocarcinoma.