In fact, synthetic high-density lipoprotein (HDL) nanoparticles that inhibit the cholesterol transporters SR-BI inhibited cortisol production in ACC cell lines and enhanced the apoptosis induced by etoposide, cisplatin or mitotane.[86] Synthetic HDL nanoparticles are undergoing active investigation as novel anti-cancer agents and hold promise for the treatment of ACC.[87, 88]. The gene discussed is SCARB1; the disease is adrenal cortex carcinoma.