Genetic studies have identified disturbances in other signaling pathways such as the FGFR cascade.[79, 80] For instance, FGFR4 has been found to be overexpressed in ACC, particularly in the pediatric population.[81] FGFR4 expression was assessed in 57 ACC tumors with overexpression demonstrated in 65% of specimens. Here, FGFR4 is linked to adrenal cortex carcinoma.