Our study of PCNSL consolidates the importance of not only reporting the mere MUT-TP53 number, but combines the structural classification in the survival analyses, stressing the inverse association to outcome when PCNSL patients harbor hotspot/direct DNA contact MUT-TP53, as formerly shown in DLBCL and other cancer subtypes [12, 26, 35, 42]. The gene discussed is TP53; the disease is cancer.