DS-epi1, which was originally referred to as squamous cell carcinoma antigen recognized by cytotoxic T lymphocytes 2 (SART2) (Nakao et al., 2000; Maccarana et al., 2006), is overexpressed in all tumors and functionally linked to the tumorigenic properties of esophagus squamous cell carcinoma that involve cell migration (Thelin et al., 2012). The gene discussed is DSE; the disease is esophageal squamous cell carcinoma.