In a paper published by Kostadima et al.[30], no association of KISS1 expression was found with genes that regulate cell-cycle and proliferation such as HER2, VEGF and p53. Indeed, it was shown that proliferation of breast epithelial or breast cancer cell lines including MCF-7 and MDA-MB-231, expressing the receptor endogenously or exogenously, was not affected by KP-10[30–32]. This evidence concerns the gene VEGFA and breast carcinoma.