As MS progresses, acute inflammatory lesions develop when the integrity of the blood–brain barrier is disturbed, with CD4+ Th1, Th17 cells, and CD8+ cells becoming activated by mature dendritic cells [67].Various studies have demonstrated that helminth-infected patients with MS have fewer relapses and inflammatory changes than uninfected patients, while removal of helminth infection exacerbates MS disease [68–70]. Here, CD4 is linked to myeloid sarcoma.