No significant differences were seen between treated or untreated patients or according to the presence of markers of worse prognosis (CD38, ZAP-70, cytogenetic alterations, IgVH mutational status), with the exception of IgVH mutational status, with unmutated IgVH CLL samples showing a higher resistance to apoptosis induced by deguelin (median ED50: 9 μM vs 5 μM, respectively). The gene discussed is ZAP70; the disease is B-cell chronic lymphocytic leukemia.