CD5 and B-cell chronic lymphocytic leukemia: In combination with fludarabine, deguelin remarkably potentiates fludarabine-induced dsDNA strand breaks showing a mild synergistic effect in vitro on human CLL cells and NZB CLL-like cells, and prolongs survival in an experimental model of CLL established by transfer of splenocytes from old NZB mice with leukemic hyperdiploid CD5+ B cells into young NZB recipients.