Similar to the effect in human CLL cells, deguelin induced apoptosis in NZB CLL-like cells in a dose-dependent manner (Fig 6A), and led to downregulation of AKT, NFκB (p65) activity, IκBα and the antiapoptotic proteins cIAP and XIAP (Fig 6B). Here, NFKB1 is linked to B-cell chronic lymphocytic leukemia.