The early involvement of ANGPTL2 in the pathogenesis of chronic inflammatory diseases in humans is supported by the elevated plasma ANGPTL2 concentration detected in patients suffering from CVD [4–6, 9], diabetes [5, 10, 11] and obesity [5, 12, 13] alongside other classical markers of inflammation such as C-reactive protein (CRP) [14, 15]; a positive correlation between serum CRP and ANGPTL2 has previously been reported in diabetic patients [5]. This evidence concerns the gene ANGPTL2 and obesity due to melanocortin 4 receptor deficiency.