These findings are in line with a study by Chen and colleagues who used immunohistochemistry and described that high expression of CD133 was positively associated with tumor invasion depth, presence of distant metastasis, advanced TNM stage and shorter survival in patients with gastric carcinoma [43] Also other markers, such as circulating entothelial cells (CEC) which were shown to correlate with vascular damage, were investigated, recently. This evidence concerns the gene PROM1 and gastric carcinoma.