To further determine whether EPHA3 indeed exerts its function on SCLC chemoresistance, we conducted the rescue experiment by co-transfecting the stably silenced cells (H69 EPHA3 shRNA and H1688 EPHA3 shRNA) and their corresponding EPHA3 shRNA NC cells with the plasmids EPHA3-PEX2-EcoRI/BamHI and EPHA3-PEX2 NC, respectively. Here, EPHA3 is linked to small cell lung carcinoma.