BMX was confirmed to be a critical downstream target of the constitutively active PI3-kinase in PTEN-deficient prostate cancer cells, and BMX was shown to activate the signal transducer and activator of transcription 3 (STAT3) signaling to maintain self-renewal and tumorigenic potential of glioblastoma stem cells [33, 34]. Here, STAT3 is linked to glioblastoma.