Moreover, both PI3K inhibitor LY294002 and BMX inhibitor LFM-A13 reduced the phosphorylation of BMX and/or STAT3 in the stably EPHA3 silenced SCLC cells, and increased sensitivity of these cells to chemotherapy drugs, which coincided with the observation that the survival of the cisplatin-resistant SCLC cell lines was well suppressed by BEZ235, accompanied by the suppression of S6RP phosphorylation [48]. The gene discussed is PIK3CA; the disease is small cell lung carcinoma.