At multivariate analysis, indeed, the presence of increased hs-cTnT and of RBBB emerged as independent predictors of VEBs>1190/24h on ECG-Holter; this finding leads us to speculate about the prognostic importance of an high-risk association between these warning biomarkers in SSc, taking into account the fact that both hs-cTnT and RBBB are two recently described poor prognostic factors in SSc patients [7,22]. The gene discussed is TNNT2; the disease is systemic sclerosis.