It has been reported that miR-92b could target Dickkopf-3 (DKK3) and Nemo-like kinase (NLK) to regulate Wnt/β-catenin signaling in glioma cells.23, 24 Unfortunately, there was no significant downregulation of DKK3 and NLK in HCC tissues compared with ANLTs (data not shown), which was consistent with the results from previous reports.25, 26, 27 Neither DKK3 nor NLK had the inverse relationship with miR-92b expression in HCC tissues, implying DKK3 and NLK might not be key downstream targets of miR-92b in HCC progression. The gene discussed is NLK; the disease is hepatocellular carcinoma.