To characterize the molecular pathways affected by Gal-1 in HCC cells, we examined two microarray-based global gene expression profiling studies of cancer cells with endogenous forced Gal-1 levels or Gal-1 knockdown.21, 22 We speculated that the αv- and β3-integrin subunits may be candidate Gal-1 targets. The gene discussed is GAL; the disease is cancer.