GAL and hepatocellular carcinoma: The median OS was 9.0 months in the Gal-1-high group and 14.0 months in the Gal-1-low group (Gal-1-high group hazard ratio 2.879; 95% confidence interval, 1.019–6.271; P<0.05); therefore, we conclude that high levels of Gal-1 lead to HCC sorafenib resistance.