A previous study reported that the hyperactivation of PI3K signaling is responsible for EMT, primarily via the PI3K/AKT/Snail/PTEN feedback loop.6 The results obtained thus far indicated that the FAK/PI3K/AKT signaling may mediate HCC EMT owing to high expression of Gal-1. This evidence concerns the gene PTEN and hepatocellular carcinoma.