NFAT5 and breast cancer: The signaling through α6β4 integrin activates NFAT1, NFAT4 and NFAT5.7 Consistent with these data, the Akt-dependent NFAT1 ubiquitination and its subsequent degradation proteasome resulted in impaired migratory and invasive potential of the breast cancer cell lines.124, 125 NFAT1 also regulates the invasion of glioblastoma multiforme cells126 and metastasis of mammary cancer cells.127 NFAT1 was also found ectopically expressed in the nucleus of pancreatic tumors.