NFAT2 directly induces the transcription of DDIAS,94 an anti-apoptotic protein highly expressed in lung cancers.95 A positive correlation between DDIAS and NFAT2 expression was found in human lung tumors, and inhibition of NFAT2 or DDIAS increased cell death in the presence of cisplatin, providing insights into DDIAS-associated chemoresistance via NFAT2 activation.94 This evidence concerns the gene NFATC1 and lung cancer.