It was shown that an inflammatory microenvironment induces NFAT1 activity, which in turn contributes to tumor growth.46, 77 Furthermore, a crucial role for NFAT1 in initiation and promotion of inflammation-associated colorectal tumors was reported.128 In addition, some recent studies have implicated NFAT factors with the dedifferentiation of cancer cells. Here, NFATC2 is linked to colorectal neoplasm.