ADCY10 and hydrops fetalis: This confirms that MPT is altered in HF, which could make mitochondria more vulnerable to Ca2+ overload.46 Interestingly, mitochondria from HF rats still responded to HCO3− stimulation of mitochondrial cAMP production by sAC, by delaying ΔΨm loss, Ca2+ entry and MPT (i.e. matrix swelling).