CIP2A and infection: Notably, after the second infection with a lethal dose, when compared to WT mice, CIP2AHOZ mice did present a significant increase in large bacterial abscesses in the liver (Fig 2E and 2F) (p = 0.03), as well as a trend for higher splenic bacterial load (S2C Fig), indicating for a reduced adaptive immune response in CIP2A-deficient mice.