BCR and chronic myelogenous leukemia, BCR-ABL1 positive: The other study indicates the link between HO-1 and Bcr/Abl fusion gene in chronic myelogenous leukemia (CML) [199], whereas in kidney cancer the activation of Ras pathway and the stimulation of downstream signaling, including Raf and ERK, lead to Nrf2 activation and HO-1 induction [200].