However, human genome epidemiology (HuGE) meta-analysis of HO-1 polymorphism and susceptibility to coronary artery disease (CAD) from 11 studies, involving 10,170 patients with CAD and 6868 controls, performed in 2014 by Qiao et al. [79] revealed no significantly decreased risk of CAD in patients with the SS genotype of the HO-1 (GT)n repeat length polymorphism compared with those with the LL + SL genotype. Here, HMOX1 is linked to coronary artery disorder.