In the recent paper by Wang et al., transgenic flies with mutated α-synuclein (A53T), showing neurodegenerative changes characteristic for PD, were protected by bardoxolone methyl (CDDO-Me), Nrf2 inducer, through ROS scavenging and the activation of Nrf2/antioxidant response element signaling pathway. This evidence concerns the gene NFE2L2 and Parkinson disease.