HLA-DRB1 and interstitial lung disease: However, the combination of HLA-B*15:01 and DRB1*15:01 was observed in 2 of the 4 patients (50 %) who developed ILD, while only 1 of 53 patients (2 %) who did not develop ILD harbored this combination, resulting in an odds ratio (OR) of 52.0 (95 % CI 3.2–842.5; p = 0.01, Table 2).