Taking into account the constitutive levels of bmp6, highest in the liver but also considerably high in the posterior intestine, we cannot discard the possibility that, at least in teleost fish, although the liver seems to be the major regulator of bmp6 levels, there might be some contribution by the intestinal cells when the anemia is more severe, further fueling the controversy regarding the cellular origin of BMP6 [34, 35]. Here, BMP6 is linked to anemia (phenotype).