In addition, a considerable number of our patients in remission were treated with colchicine, the mode of action of which is to inhibit the NALP3 inflammasome.48 Thus, inflammatory cytokines in remission could be pharmacologically suppressed by colchicine, and this may not reflect the nature of cytokine networks of FMF patients in remission. This evidence concerns the gene NLRP3 and familial Mediterranean fever.