In line with these observations, it is widely known that elevated acute-phase proteins such as serum amyloid A and C-reactive protein and inflammatory cytokines including IL-6 and IL-18 are implicated in the disease activity of FMF in clinical practice.3,9,10 However, a specific biomarker for FMF is not yet available, and the cytokine profile in serum from FMF patients in attacks associated with its pathogenesis has not been established. Here, IL18 is linked to familial Mediterranean fever.