CRP and familial Mediterranean fever: In line with these observations, it is widely known that elevated acute-phase proteins such as serum amyloid A and C-reactive protein and inflammatory cytokines including IL-6 and IL-18 are implicated in the disease activity of FMF in clinical practice.3,9,10 However, a specific biomarker for FMF is not yet available, and the cytokine profile in serum from FMF patients in attacks associated with its pathogenesis has not been established.