Although little is known about the physiological roles of IFI27 in podocyte, our results suggest that IFI27 might also be important for normal podocyte function after viral attack, and that glomeruli in which IFI27 is persistently down-regulated by continuous bacterial infection might be vulnerable to kidney injury from CGN, in particular IgAN and MN. This evidence concerns the gene IFI27 and bacterial infectious disease.