The purpose of this study was to investigate pre-therapeutic Ang2, Ki-67 and CD31 expression in the primary human RCC tissue in patients with metastatic disease, the correlation of baseline Ang2 and Ki-67 expression with tumour vascular content and the relation of their expression to the outcome of first-line sunitinib treatment in patients with mRCC. The gene discussed is MKI67; the disease is neoplasm.