POLE and colorectal carcinoma: Two adenomas, 1 sessile serrated adenoma MDA51ad-SSA and 1 tubular adenoma MDA50ad-TA exhibit multiple mutations in WNT and RAS/PI3K pathways, and hypermutation-associated genes, such as mismatch-repair gene MLH1 and PMS2 [12, 19], and DNA polymerase epsilon POLE, which has frequent mutations in hypermutated CRC tumors [12].