The aim of our study was to analyze the contribution of combinations of thepolymorphic markers rs1024611 (-2518A>G, CCL2 gene),rs1799864 (V64I, CCR2 gene), rs3732378 (T280M, CX3CR1gene), rs1136743 (A70V, SAA1 gene), and rs1205(2042C>T, CRP gene) to the formation of geneticpredisposition to CHD. The gene discussed is CRP; the disease is coronary artery disorder.