PROMPT has scope beyond addressing these questions for PALB2 alone and will support the rapid translation of similar information for several new breast cancer predisposition genes including ATM, CDH1, CHEK2, RAD51C, RAD51D, STK11, TP53 in addition to BRCA1 and BRCA2. PROMPT is an online research registry for people who have undergone gene panel testing and been found to have a genetic variation in one of the above genes. Here, CHEK2 is linked to breast cancer.