Norquist et al. have reported findings from a targeted capture and massively parallel sequencing assay that included the identification of 12 PALB2 mutation carriers in a group of 1,915 women with ovarian cancer unselected for family history (P = <0.001 when compared to data from the Exome Sequencing Project and the Exome Aggregation Consortium) [35]. The gene discussed is PALB2; the disease is ovarian cancer.