Ten-year survival for women with breast cancer and a PALB2 mutation was 48.0 % (95 % CI, 36.5 %–63.2 %), compared with 74.7 % (95 % CI, 73.5 %–75.8 %) for non-carriers (hazard ratio for death 2.27, 95 % CI, 1.64–3.15; p < 0.0001) [40]. This evidence concerns the gene PALB2 and breast carcinoma.