Autosomal recessive forms of microcephaly with chorioretinopathy are caused by mutations of the genes of the master regulator of centriole duplication, the PLK4 kinase (MCCRP2, MIM 616171) [17], and their substrates TUBGCP4 (MCCRP3, MIM 616335) [18] and TUBGCP6 (MCCRP1, MIM 251270) [17]. Here, TUBGCP6 is linked to microcephaly.