CXCL8 and hantavirus infectious disease: IL-8 (CXCL8) is another potent neutrophil chemoattractant that can be produced by a number of cell types in the respiratory tract, including activated alveolar macrophages, airway epithelial, airway smooth muscle, and airway endothelial cells responding to inflammatory stimuli (76, 77), but like MIP-1a, MIP-2, and MCP-1, there are only limited data on how these chemokines are regulated during human hantavirus infection.