To test the protein level of KIAA1522 in a relatively large sample size and to examine the potential relevance with clinical parameters, immunohistochemistry (IHC) assays were performed to detect KIAA1522 expression in tissue microarrays (TMAs) containing 583 NSCLC tissues and their paired non-tumor tissues. The gene discussed is NHSL3; the disease is non-small cell lung carcinoma.