In agreement with the prognostic role of KIAA1522 and its association with chemo-sensitivity, we found the enrichment of KRAS down-stream signaling genes within KIAA1522 high expression groups of lung cancer and the reciprocal regulation between KIAA1522 expression level and the activation of oncogenic RAS signaling in vitro (Fig. 6). This evidence concerns the gene NHSL3 and lung cancer.