In the case of WSE, there have been association with NSCLC and adenocarcinoma histology, EGFR mutations, a reverse association with KRAS mutations and higher response to EGFR-TKIs [15] making it a distinctive disease entity inside the group of never smokers which would be a good candidate for personalized diagnostic and therapeutic approaches. The gene discussed is KRAS; the disease is non-small cell lung carcinoma.