These observations are in contrast to findings of overexpression in carcinomas of other sites with worse prognosis: HSP70 overexpression in colon cancer with low tumor differentiation and advanced tumor stage34, strong expression of HSP27 and 60 in prostate cancer with shorter recurrence free survival35, or in HCC where high HSP70 expression correlated with higher tumor stage, greater tumor size and invasiveness36. Here, HSPB1 is linked to Familial prostate cancer.