Furthermore, a soluble form of endoglin (S-endoglin), generated by the cleavage of the extracellular domain of the entire endoglin molecule, has also been suggested as a marker of ED and reported to be increased in the serum of patients with preeclampsia, hypercholesterolemia, and atherosclerosis (9,10,11,12). The gene discussed is ENG; the disease is Hypercholesterolemia.