In support of this notion, previous studies in HIV+ children and HIV-Tg26 mice with renal diseases showed an up-regulated expression of renal HSPG [10, 11], and high urinary levels of Vascular Endothelial Growth Factor-A (VEGF-A) and Fibroblast Growth Factor-2 (FGF-2) were detected in patients with HIV-renal diseases [9, 11–14]. This evidence concerns the gene VEGFA and kidney disorder.