PAI-1-mediated renal fibrosis is strongly associated with TGF-β1; PAI-1 level and interstitial collagen deposition were highly increased in TGF-β1 transgenic mice and on the contrary, pai-1 deficiency prevented TGF-β1-induced renal fibrosis and ECM accumulation [62]. Here, TGFB1 is linked to renal fibrosis.