The lead compound, 2-chloro-3-(4, 5-diphenyl-1H-imidazol-2-yl) pyridine (CIP) suppressed the proliferation of breast cancer cells, decreased the phosphorylation of PDK, Akt, mTOR, downregulated the cellular invasion and activated caspases and cleaved PARP to induce apoptosis. This evidence concerns the gene AKT1 and breast carcinoma.