Indeed, low or complete absence of XAF1 expression (0 and 1+) is correlated with poor prognosis and reduced survival of neuroblastoma patients compared to moderate or high XAF1 expression (2+ and 3+) as indicated by the Kaplan-Meier curves, providing further evidence to suggest that XAF1 may be a potential tumor suppressor (Figure 2E, 2F and Supplementary S2C). Here, XAF1 is linked to neoplasm.