Wang P and Guan PP et al indicated that shear stress with 2 dyn/cm2 increased the release of cyclic AMP and interleukin-1β via the induction of MMPs (MMP-1, MMP-7 and MMP-12) in PI3-K and ERK1/2-dependent manner, which significantly promoted motility and invasion of chondrosarcoma cells [39, 40]. This evidence concerns the gene MAPK3 and chondrosarcoma.