These mice also had a higher proportion of apoptotic cells in the tumor mass: Figure 6C shows that GL261-RFP-bearing mice treated with TMZ/TRAM-34 had increased Annexin-V positive cells (green) in the tumor core (red cells) in comparison with vehicle-treated or TRAM-34 and TMZ treated mice after 21 days. The gene discussed is ANXA5; the disease is neoplasm.