Furthermore, the association of eGFR with hs-cTn concentrations remained equally strong when subdividing this cohort into patients with no (hs-cTnT:stβeGFR:-0.295; hs-cTnI:stβeGFR:-0.228), mild (hs-cTnT:stβeGFR:-0.290; hs-cTnI:stβeGFR:-0.176) and moderate-to-severe CAD (hs-cTnT:stβeGFR:-0.293;hs-cTnI: stβeGFR:-0.249) (all p<0.001), confirming the independent influence of eGFR on hs-cTn concentrations beyond CAD severity (S1 Table). The gene discussed is TNNI3; the disease is coronary artery disorder.