To this end, the FDA approval of Sipuleucell T for the treatment of hormone refractory prostate cancer set the stage in 2010 [1], followed by the more recent approvals of the PD-1 and CTLA-4 checkpoint inhibitory monoclonal antibodies (mAb) in melanoma and non-small cell lung cancer (NSCLC) [2]. This evidence concerns the gene CTLA4 and non-small cell lung carcinoma.