Because IL-2 regulates the differentiation of the TH1, TH2, and TH17 CD4+ T helper cell subsets [4, 5, 6], we hypothesized that part of the mechanism by which IL-2 counteracts autoimmunity could be via an alteration in the balance of these cell types and the cytokines that they produce. This evidence concerns the gene IL2 and Autoimmunity.