These results suggest that, although S63del//Perk+/− mice seem to phenocopy S63del//Perk+/− mice, the amelioration of neuropathy observed here is likely to be independent from Chop. Therefore, we considered other candidates for S63del//Perk+/− rescue, for example, in the other UPR pathways. This evidence concerns the gene EIF2AK3 and neuropathy.