Medication such as beta-blockers, statins, calcium channel blockers, aspirin or angiotensin converting enzyme inhibitors/angiotensin receptor blockers (Additional file 1: Figure S2) as well as cardiovascular risk factors such as hypertension (yes vs no, n = 35/58, −0.507 ± 0.344 vs −0.518 ± 0.307, P = 0.877), dyslipidaemia (yes vs no, n = 42/45, −0.486 vs −0.545, P = 0.403), smoking history (yes vs no, n = 43/44, −0.542 ± 0.348 vs −0.498 ± 0.300, P = 0.510), and diabetes (yes vs no, n = 4/93, −0.795 [−0.850; −0.73] vs −0.560 [−0.738; −0.302], P = 0.280) did not impact on the CAD238 score. This evidence concerns the gene ACE and diabetes mellitus.