EZH2 and melanoma: Those three melanomas presented also amplification of 7q36.1 (amplicon size, 78 genes), which includes the epigenetic modifier EZH2. Amplification of EZH2 locus in melanomas that developed metastasis is consistent with the higher EZH2 mRNA expression in metastatic compared with primary melanomas (p < 0.001) in public microarrays (Figure 3B).