SIRPA and multiple sclerosis: It was reported that CD47 expression is decreased in human brain lesions of multiple sclerosis (MS), a CNS autoimmune neuroinflammatory disease, whereas SIRP-α expression is unchanged, suggesting that decreased CD47 expression contribute to a disturbed equilibrium in macrophage and microglia activation in MS lesions and may result in a proinflammatory predisposition in the area surrounding chronic active lesions [44].