In the present study, we demonstrate that the expression of the immune inhibitory molecules CD47 and its receptor, SIRP-α, and CD200 are downregulated in surgically resected brain tissues from patients with FCD IIb and TSC, both of which are associated with medically intractable pediatric epilepsy, whereas the expression of CD200 receptor, CD200R, is not significantly altered. Here, SIRPA is linked to tuberous sclerosis.