Similar to that in mRNA expression, the protein levels of CD47, SIRP-α, and CD200 were downregulated in both the FCD IIb and TSC lesions compared with control tissues (P < 0.05; Fig. 2a–d), while the CD200R protein level was not significantly altered (P > 0.05; Fig. 2c, d). The gene discussed is CD200R1; the disease is tuberous sclerosis.