To assess the potential roles of CD47 and CD200 on the epileptogenesis of FCD IIb and TSC, we examined the concentrations of several proinflammatory cytokines (IL1-β, IL-6, and IL-17), which are associated with the epileptogenesis of FCD IIb and TSC [15–17, 30], in living epileptogenic brain slices treated with soluble recombinant human CD47 Fc chimera protein or CD200 Fc chimera protein compared with the vehicle-treated controls. The gene discussed is CD200; the disease is tuberous sclerosis.