We speculate that increasing CD47/SIRP-α and CD200/CD200R expression may also have protective roles in FCD IIb and TSC, since we have revealed that CD47 Fc and CD200 Fc could reduce IL-6 release, a key proinflammatory cytokine involved in FCD IIb and TSC. The gene discussed is CD200; the disease is fleck corneal dystrophy.