These characteristics of the EFEMP1 methylation pattern in IPMN carcinogenesis appeared similar to those of MGMT, SFRP2, and RASSF2 in the adenoma-carcinoma sequence of colorectal cancer (Nagasaka et al. 2008, 2009; Takeda et al. 2011). Here, RASSF2 is linked to pancreatic intraductal papillary-mucinous neoplasm.