KRAS mutation frequency tended to increase with IPMN grade: 12 of 31 were low grade (39 %), 6 of 11 were high grade (55 %), and 16 of 23 were invasive Ca (70 %, p = 0.084; low-grade vs. high-grade/invasive Ca). Here, KRAS is linked to pancreatic intraductal papillary-mucinous neoplasm.